Electrophysiological Effects of an Anti-influenza Drug Oseltamivir on the Guinea-Pig Atrium: Comparison with Those of Pilsicainide

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  • Takahara Akira
    Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
  • Suzuki Sanae
    Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
  • Hagiwara Mihoko
    Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
  • Nozaki Shuhei
    Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
  • Sugiyama Atsushi
    Department of Pharmacology, Faculty of Medicine, Toho University

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Abstract

We assessed the effects of oseltamivir on the conduction velocity and effective refractory period in the guinea-pig atrium in comparison with those of a class Ic antiarrhythmic drug pilsicainide. The recording and stimulating electrodes were attached on the epicardium close to the sinus nodal region and on the left atrial appendage. Oseltamivir (10–100 µM) as well as pilsicainide (1–10 µM) decreased the atrial conduction velocity in a frequency-dependent manner. Both drugs also increased the effective refractory period in both atria; but the frequency-dependent property of oseltamivir was lacking in the left atrium, and it was less obvious in the right atrium compared with that of pilsicainide. These results suggest that oseltamivir can directly modify the electrophysiological functions in the guinea-pig atrium possibly via combination of Na+ and K+ channel-blocking actions.

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