Gelsenicine from Gelsemium elegans Attenuates Neuropathic and Inflammatory Pain in Mice
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- Liu Ming
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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- Shen Jie
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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- Liu Hao
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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- Xu Ying
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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- Su Yan-Ping
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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- Yang Jian
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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- Yu Chang-Xi
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
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Abstract
Gelsemium elegans BENTH and its crude extract are widely used to treat pain in China despite its apparent toxicity. The analgesic effects of gelsenicine, an active component of G. elegans, however, have not been reported. The current study examined potential analgesic effects of subcutaneously injected gelsenicine using acetic acid-induced writhing, formalin-induced nociceptive behavior, and thermal hyperalgesia caused by chronic constriction injury (CCI) in mice. Gelsenicine produced dose-dependent analgesic effects in both inflammatory and neuropathic pain models. The ED50, for either the inflammatory pain (10.4 μg/kg for writhing test, 7.4 μg/kg for formalin test) or neuropathic pain (9.8 μg/kg for thermal hyperalgesia caused by CCI model), was far below the LD50 (95% confidence interval at 100—200 μg/kg). Repeated subcutaneous injections of gelsenicine in CCI mice led to sustained attenuation of neuropathic pain after drug discontinuation. These results revealed that gelsenicine could be used safely to attenuate both inflammatory and neuropathic pain.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 34 (12), 1877-1880, 2011
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679609105408
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- NII Article ID
- 130001872610
- 40019073719
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 023323561
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed