Sauchinone, a Lignan from <i>Saururus chinensis</i>, Protects Human Skin Keratinocytes against Ultraviolet B-Induced Photoaging by Regulating the Oxidative Defense System

DOI Web Site Web Site PubMed 4 References
  • Park Gunhyuk
    Department of Life and Nanopharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University
  • Kim Hyo Geun
    Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University
  • Sim Yeomoon
    Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University
  • Sung Sang Hyun
    Institute for Life Science, Elcomscience Co., Ltd., and College of Pharmacy, Seoul National University
  • Oh Myung Sook
    Department of Life and Nanopharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University

Bibliographic Information

Other Title
  • Sauchinone, a Lignan from Saururus chinensis, Protects Human Skin Keratinocytes against Ultraviolet B-Induced Photoaging by Regulating the Oxidative Defense System

Search this article

Abstract

Ultraviolet (UV) radiation from sunlight induces matrix metalloproteinase (MMP) expression, which are responsible for collagenous extracellular matrix proteins breakdown in skin, causing photoaging. Sauchinone is reported to have various bioactivity such as antioxidative, hepatoprotective, and anti-inflammatory effects. In the present study, we investigated the protective effect of sauchinone against UVB (50 mJ/cm2)-induced photoaging in HaCaT human epidermal keratinocytes. Sauchinone, at 5–40 µM, significantly protected keratinocytes against UVB-induced damage as assessed by cell viability and toxicity assay. Additionally, sauchinone, at 20–40 µM, prevented the upregulation of MMP-1 proteins and reduction of type 1 collagen induced by UVB. Other assays revealed that, in keratinocytes, sauchinone decreased reactive oxygen species (ROS) production and increased glutathione levels and heme oxygenase-1. Sauchinone also inhibited UVB-induced phosphorylation of mitogen-activated protein kinase (MAPK) signaling pathways. These results demonstrated that sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes.

Journal

References(4)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top