Ultrasound-Assisted Extraction of Pristimerin from <i>Celastrus orbiculatus</i> Using Response Surface Methodology
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- Fang Gong
- College of Pharmacy, Guangdong Pharmaceutical University
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- Li Guocheng
- Department of Pharmacy, ZengCheng People’s Hospital
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- Pang Chaohai
- College of Pharmacy, Guangdong Pharmaceutical University
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- Li Wenxi
- College of Pharmacy, Guangdong Pharmaceutical University
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- Wang Dingyong
- College of Pharmacy, Guangdong Pharmaceutical University
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- Liu Chunxia
- Department of Pharmacy, ZengCheng People’s Hospital
Bibliographic Information
- Other Title
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- Ultrasound-Assisted Extraction of Pristimerin from Celastrus orbiculatus Using Response Surface Methodology
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Abstract
This paper describes the ultrasound-assisted extraction (UAE) of pristimerin from Celastrus orbiculatus. Methanol was the most effective for pristimerin extraction, followed by ethanol, ethyl acetate, n-butanol, and water. To optimize the conditions, the Box–Behnken design, a widely used form of response surface methodology, was used to investigate the effects of parameters on UAE. Several variables, such as extraction time, ultrasonic power, extraction temperature, and solvent-to-solid (S/S) ratio were investigated. The highest extraction yield of 1.843 mg/g was obtained using methanol under optimal conditions with an extraction time of 40 min, ultrasonic power of 105 W, an S/S ratio of 40 mL/g, and an extraction temperature of 52°C. The experimental values under optimal conditions agreed well with the predicted values, suggesting that UAE has good potential as an extraction method for pristimerin from C. orbiculatus.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 39 (1), 97-103, 2016
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679609280384
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- NII Article ID
- 130005116510
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 027013105
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- PubMed
- 26466608
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed