Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells

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  • Zhang Zhenwei
    Department of Biochemistry and Molecular Biology, Second Military Medical University Department of Biochemistry and Molecular Biology, Second Military Medical University, P. R. China
  • Miao Lei
    Department of Pharmacology, Zhejiang Chinese Medical University Department of Pharmacology, Zhejiang Chinese Medical University
  • Sun Weizhang
    PET Center, General Hospital of Chengdu Military command PET Center, General Hospital of Chengdu Military Command
  • Jiao Binghua
    Department of Biochemistry and Molecular Biology, Second Military Medical University Department of Biochemistry and Molecular Biology, Second Military Medical University, P. R. China
  • Wang Bingui
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
  • Yao Li
    Department of Pharmacology, Zhejiang Chinese Medical University Department of Pharmacology, Zhejiang Chinese Medical University
  • Huang Caiguo
    Department of Biochemistry and Molecular Biology, Second Military Medical University Department of Biochemistry and Molecular Biology, Second Military Medical University, P. R. China

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  • Wentilactone B from <i>Aspergillus wentii</i> Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells

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Wentilactone B (EN-48-57) is one of the six derivatives separated from Aspergillus wentii (EN-48). Of these derivatives, Wentilactone B exerted a more significant antibacterial and cytotoxic activity in several tumor cell lines. The present study demonstrates that Wentilactone B could efficiently induce SMMC-7721 cells apoptosis, but not normal hepatic cells, as measured by an inverted microscope, 4′,6-diamidino-2-phenylindole staining and flow cytometry. In addition, Wentilactone B could inhibit the metastasis of SMMC-7721 cells, which was detected by colony formation, scratch migration and a transwell assay, and could induce a series of intracellular events, including the down-regulation of CD44 and epidermal growth factor receptor proteins. In conclusion, Wentilactone B inhibited the growth of SMMC-7721 cells by triggering apoptosis and inhibiting metastasis.

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