Curcumin Ameliorates Cardiac Inflammation in Rats with Autoimmune Myocarditis
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- Mito Sayaka
- Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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- Watanabe Kenichi
- Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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- Harima Meilei
- Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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- Thandavarayan Rajarajan Amirthalingam
- Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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- Veeraveedu Punniyakoti Thanikachalam
- Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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- Sukumaran Vijayakumar
- Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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- Suzuki Kenji
- Third Department of Medicine, Graduate School of Medical and Dental Sciences, Niigata University
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- Kodama Makoto
- First Department of Medicine, Graduate School of Medical and Dental Sciences, Niigata University
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- Aizawa Yoshifusa
- First Department of Medicine, Graduate School of Medical and Dental Sciences, Niigata University
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Abstract
Curcumin is a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric, Curcuma longa. It is commonly used as a dietary spice and coloring agent in cooking, and is used anecdotally as an herb in traditional Indian and Chinese medicine. It has been reported that curcumin has the potential to protect against cardiac inflammation through suppression of GATA-4 and nuclear factor-κB (NF-κB); however, no study to date has addressed the effect of curcumin on experimental autoimmune myocarditis (EAM) in rats. In this study, 8-week-old male Lewis rats were immunized with cardiac myosin to induce EAM. They were then divided randomly into a treatment or vehicle group and orally administrated curcumin (50 mg/kg/d) or 1% gum arabic, respectively, for 3 weeks after myosin injection. We performed hemodynamic, echocardiographic, hematoxylin and eosin staining, mast cell staining and Western blotting studies to evaluate the protective effect of curcumin in the acute phase of EAM. Cardiac functional parameters measured by hemodynamic and echocardiographic studies were significantly improved by curcumin treatment. Furthermore, curcumin reduced the heart weight-to-body weight ratio, area of inflammatory lesions and the myocardial protein level of NF-κB, interleukin (IL)-1β, tumor necrosis factor (TNF)-α and GATA-4. Our results indicate that curcumin has the potential to protect against cardiac inflammation through suppression of IL-1β, TNF-α, GATA-4 and NF-κB expresses, and may provide a novel therapeutic strategy for autoimmune myocarditis.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 34 (7), 974-979, 2011
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679609455872
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- NII Article ID
- 130000738083
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 11132375
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed