Repeated Cold Stress Enhances the Acute Restraint Stress-Induced Hyperthermia in Mice
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- Miyamoto Tomoyoshi
- Faculty of Pharmacy, Kindai University Department of Pharmacy, Seichokai Fuchu Hospital
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- Funakami Yoshinori
- Faculty of Pharmacy, Kindai University
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- Kawashita Erika
- Faculty of Pharmacy, Kindai University
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- Nomura Ai
- Faculty of Pharmacy, Kindai University
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- Sugimoto Nanako
- Faculty of Pharmacy, Kindai University
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- Saeki Haruka
- Faculty of Pharmacy, Kindai University
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- Tsubota Maho
- Faculty of Pharmacy, Kindai University
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- Ichida Seiji
- Faculty of Pharmacy, Kindai University
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- Kawabata Atsufumi
- Faculty of Pharmacy, Kindai University
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説明
<p>The rodents exposed to repeated cold stress according to a specific schedule, known as specific alternation of rhythm in temperature (SART), exhibit autonomic imbalance, and is now used as an experimental model of fibromyalgia. To explore the susceptibility of SART-stressed animals to novel acute stress, we tested whether exposure of mice to SART stress for 1 week alters the extent of acute restraint stress-induced hyperthermia. Mice were subjected to 7-d SART stress sessions; i.e., the mice were alternately exposed to 24 and 4°C at 1-h intervals during the daytime (09:00–16:00) and kept at 4°C overnight (16:00–09:00). SART-stressed and unstressed mice were exposed to acute restraint stress for 20–60 min, during which rectal temperature was monitored. Serum corticosterone levels were measured before and after 60-min exposure to restraint stress. SART stress itself did not alter the body temperature or serum corticosterone levels in mice. Acute restraint stress increased the body temperature and serum corticosterone levels, both responses being greater in SART-stressed mice than unstressed mice. The enhanced hyperthermic responses to acute restraint stress in SART-stressed mice were significantly attenuated by SR59230A, a β3 adrenoceptor antagonist, but unaffected by diazepam, an anxiolytic, mifepristone, a glucocorticoid receptor antagonist, or indomethacin, a cyclooxygenase inhibitor. These results suggest that SART stress enhances the susceptibility of mice to acute restraint stress, characterized by increased hyperthermia and corticosterone secretion, and that the increased hyperthermic responses to acute stress might involve accelerated activation of sympathetic β3 adrenoceptors, known to regulate non-shivering thermogenesis in the brown adipose tissue.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 40 (1), 11-16, 2017
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679609528192
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- NII論文ID
- 130005188787
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 027818710
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- PubMed
- 28049943
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可