Cardamonin Suppresses the Proliferation of Colon Cancer Cells by Promoting β-Catenin Degradation
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- Park Seoyoung
- Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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- Gwak Jungsug
- Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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- Han Seung Jin
- Department of Biological Science, Inje University
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- Oh Sangtaek
- Department of Advanced Fermentation Fusion Science & Technology, Kookmin University
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Aberrant accumulation of intracellular β-catenin and subsequent activation of β-catenin response transcription (CRT) in intestinal epithelial cells is a frequent early event during the development of colon cancer. Here we show that cardamonin, a chalcone isolated from Aplinia katsumadai Hayata, inhibited CRT in SW480 colon cancer cells that carry inactivating mutation in the adenomatous polyposis coli (APC) gene. Cardamonin also down-regulated intracellular β-catenin levels in SW480 cells without affecting its mRNA levels. Interestingly, pharmacological inhibition of the proteasome prevented the cardamonin-induced down-regulation of β-catenin. In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known β-catenin/T cell factor (TCF)-dependent genes. Moreover, cardamonin inhibited the growth of various colon cancer cells and induced G2/M cell cycle arrest in SW480 colon cancer cells. These findings indicate that cardamonin is a potential chemotherapeutic agent against colon cancer.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 36 (6), 1040-1044, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679610020864
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- NII論文ID
- 130003361462
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3srgsFemuw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024524516
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- PubMed
- 23538439
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可