Qingkailing Injection Alleviates Experimental Autoimmune Uveitis in Rats <i>via</i> Inhibiting Th1 and Th17 Effector Cells

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  • Tian Qingmei
    Eye Hospital, Shandong University of Traditional Chinese Medicine
  • Bi Hongsheng
    Eye Hospital, Shandong University of Traditional Chinese Medicine Eye Institute, Shandong University of Traditional Chinese Medicine Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Universities of Shandong
  • Cui Yan
    Eye Hospital, Shandong University of Traditional Chinese Medicine
  • Guo Dadong
    Eye Institute, Shandong University of Traditional Chinese Medicine Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Universities of Shandong
  • Xie Xiaofeng
    Eye Hospital, Shandong University of Traditional Chinese Medicine
  • Su Weihua
    Eye Hospital, Shandong University of Traditional Chinese Medicine
  • Wang Xingrong
    Eye Hospital, Shandong University of Traditional Chinese Medicine

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  • Qingkailing Injection Alleviates Experimental Autoimmune Uveitis in Rats via Inhibiting Th1 and Th17 Effector Cells

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Abstract

Qingkailing injection is a well-known composite formula of traditional Chinese medicine and is commonly used in clinical practice, which could offer immunomodulatory effect from our clinical experience on uveitis treatment by Qingkailing. We did the experiment in order to investigate the curative effect and mechanism of Qingkailing injection to rat experimental autoimmune uveitis (EAU). EAU was induced in Lewis rats by immunization IRBP1177–1191 in complete Freund’s adjuvant in multi-point. We found that Qingkailing injection can alleviate autoimmune uveitis in rats, inhibit the differentiation toward Th1 and Th17 effector cells and the relevant cytokines secretion. The therapeutic effect may also be regulated through increased secretion of interleukin (IL)-10.

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