Dendritic Cells—A Conductor of T Cell Differentiation—
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- Kadowaki Norimitsu
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
書誌事項
- タイトル別名
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- Dendritic Cells-A Conductor of T Cell Differentiation-
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説明
Induction of different types of adaptive immune responses depending on the nature of antigens and the environmental context is crucial to cope with a variety of pathogens and concurrently to avoid pathological reaction to self antigens. Recent studies have been elucidating that the diversity of immune responses is critically controlled by dendritic cells (DCs). Two DC subsets have been identified in humans: myeloid DCs and plasmacytoid DCs. The DC subsets induce different types of adaptive immune responses depending on environmental factors. Interleukin (IL)-12 from myeloid DCs is a dominant factor for the induction of a Th1 response, whereas OX40 ligand on myeloid DCs is important for the induction of a Th2 response. Furthermore, inducible costimulator (ICOS) ligand on plasmacytoid DCs is critical for the induction of IL-10-producing regulatory T cells. Elucidating cellular and molecular mechanisms by which functions of the two DC subsets are modulated will lead to understanding the pathogenesis of various immune-related diseases and to developing novel immunological therapies.<br>
収録刊行物
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- Allergology International
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Allergology International 56 (3), 193-199, 2007
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390282679610198272
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- NII論文ID
- 10019815131
- 130004476917
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- PubMed
- 17646736
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可