Serum Metabolomics in Rats after Acute Paraquat Poisoning
-
- Wang Zhiyi
- The Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University
-
- Ma Jianshe
- Function Experiment Teaching Center, Wenzhou Medical University
-
- Zhang Meiling
- Analytical and Testing Center, Wenzhou Medical University
-
- Wen Congcong
- Analytical and Testing Center, Wenzhou Medical University
-
- Huang Xueli
- Analytical and Testing Center, Wenzhou Medical University
-
- Sun Fa
- Analytical and Testing Center, Wenzhou Medical University
-
- Wang Shuanghu
- The Laboratory of Clinical Pharmacy, People’s Hospital of Lishui City
-
- Hu Lufeng
- Department of Clinical Pharmacy, The First Affiliated Hospital of Wenzhou Medical University
-
- Lin Guanyang
- Department of Clinical Pharmacy, The First Affiliated Hospital of Wenzhou Medical University
-
- Wang Xianqin
- Analytical and Testing Center, Wenzhou Medical University
この論文をさがす
抄録
Paraquat is one of the most widely used herbicides in the world and is highly toxic to humans and animals. In this study, we developed a serum metabolomic method based on GC/MS to evaluate the effects of acute paraquat poisoning on rats. Pattern recognition analysis, including both principal component analysis and partial least squares-discriminate analysis revealed that acute paraquat poisoning induced metabolic perturbations. Compared with the control group, the level of octadecanoic acid, L-serine, L-threonine, L-valine, and glycerol in the acute paraquat poisoning group (36 mg/kg) increased, while the levels of hexadecanoic acid, D-galactose, and decanoic acid decreased. These findings provide an overview of systematic responses to paraquat exposure and metabolomic insight into the toxicological mechanism of paraquat. Our results indicate that metabolomic methods based on GC/MS may be useful to elucidate the mechanism of acute paraquat poisoning through the exploration of biomarkers.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 38 (7), 1049-1053, 2015
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679610268416
-
- NII論文ID
- 130005086291
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 026548954
-
- PubMed
- 26133715
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可