Anti-<i>Ascaris</i> immunoglobulin E associated with bronchial hyper- reactivity in 9-year-old rural Bangladeshi children

  • Takeuchi Haruko
    Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo
  • Khan Al Fazal
    Centre for Food and Nutrition Security, International Centre for Diarrhoeal Disease Research
  • Yunus Mohammad
    Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research
  • Imrul Hasan Mohammad
    Centre for Food and Nutrition Security, International Centre for Diarrhoeal Disease Research
  • Delwer Hossain Hawlader Mohammad
    Department of Epidemiology, Bangladesh University of Health Sciences (BUHS)
  • Takanashi Sayaka
    Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo
  • Kano Hirotsugu
    Department of Pediatrics, Teikyo University School of Medicine University Hospital
  • Zaman Khalequz
    Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research
  • Chowdhury Hafizur R.
    Centre for Global Burden of Disease, Melbourne School of Population and Global Health, The University of Melbourne
  • Wagatsuma Yukiko
    Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba
  • Nakahara Shinji
    Department of Liberal Arts and Human Development, Kanagawa University of Human Services
  • Iwata Tsutomu
    Department of Education for Childcare, Faculty of Child Studies, Tokyo Kasei University

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Other Title
  • Anti-Ascaris immunoglobulin E associated with bronchial hyper-reactivity in 9-year-old rural Bangladeshi children

Description

Background: Studies have addressed the immunomodulatory effects of helminths and their protective effects upon asthma. However, anti-Ascaris IgE has been reported to be associated with an increased risk of asthma symptoms. We examined the association between serum levels of anti-Ascaris IgE and bronchial hyper-responsiveness (BHR) in children living in rural Bangladesh. Methods: Serum anti-Ascaris IgE level was measured and the BHR test done in 158 children aged 9 years selected randomly from a general population of 1705 in the Matlab Health and Demographic Surveillance Area of the International Centre for Diarrhoeal Disease Research, Bangladesh. We investigated wheezing symptoms using a questionnaire from the International Study of Asthma and Allergies in Childhood. BHR tests were successfully done on 152 children (108 ‘current wheezers’; 44 ‘never-wheezers’). We exam- ined the association between anti-Ascaris IgE level and wheezing and BHR using multiple logistic regression analyses. Results: Of 108 current-wheezers, 59 were BHR-positive; of 44 never-wheezers, 32 were BHR-negative. Mean anti-Ascaris IgE levels were significantly higher (12.51 UA/ml; 95% confidence interval (CI), 9.21 -17.00) in children with current wheezing with BHR-positive than in those of never-wheezers with BHR- negative (3.89; 2.65-5.70; t test, p < 0.001). A BHR-positive test was independently associated with anti-Ascaris IgE levels with an odds ratio (OR) =7.30 [95% CI, 2.28-23.33], p = 0.001 when adjusted for total IgE, anti-Dermatophagoides pteronyssinus IgE, pneumonia history, parental asthma, Trichuris infection, forced expiratory volume in one second, eosinophilic leukocyte count, and sex. Conclusions: Anti-Ascaris IgE level is associated with an increased risk of BHR among 9-year-old rural Bangladeshi children.

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