1-(1,3-Benzodioxol-5-yl-carbo-nyl) Piperidine, a Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor, Ameliorates Exercise-Induced Fatigue in Mice
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- Fan Wutu
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University
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- Wu Xianglong
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University
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- Pan Yalei
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University
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- Li Chenrui
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University
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- Niu Yinbo
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University
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- Zhai Yuankun
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University
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- Mei Qibing
- Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University Department of Pharmacology School of Pharmacy, Fourth Military Medical University
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説明
The current study was designed to investigate the effects of 1-(1,3-benzodioxol-5-yl-carbonyl) piperidine (1-BCP) on swimming endurance capacity which as one indicator of fatigue in the weight-loaded forced swimming mice. Mice were given either vehicle or 1-BCP (0.1, or 0.2 mmol/kg body weight daily) by intraperitoneal injection once daily for 2 weeks. The 1-BCP groups showed a significant increase in swimming time to exhaustion compared with the control group. 1-BCP increased the liver glycogen (LG) and muscle glycogen (MG) contents significantly, while decreased the lactic acid (LA) and blood urea nitrogen (BUN) levels notably compared with control group. Besides, 1-BCP treatment also significantly improved the endogenous cellular antioxidant enzymes in mice by increasing the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Therefore, this study demonstrated for the first time that the supplementation of 1-BCP, as a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor, could enhance the endurance capacity of mice and facilitated them recovery from fatigue. Thus, we provide a new effective therapeutic strategy for fatigue.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 37 (1), 13-17, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679610331904
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- NII論文ID
- 130003382112
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2c%2Fot1OjtQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 025136447
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- PubMed
- 24141261
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可