Effect of <i>Colla corii asini</i> (<i>E’jiao</i>) on <small>D</small>-Galactose Induced Aging Mice
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- Wang Dongliang
- School of Pharmaceutical Sciences, Shandong University Shandong Dong-E-E-Jiao Co., Ltd.
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- Liu Maoxuan
- School of Pharmaceutical Sciences, Shandong University
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- Cao Jichao
- School of Pharmaceutical Sciences, Shandong University
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- Cheng Yanna
- School of Pharmaceutical Sciences, Shandong University
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- Zhuo Chen
- School of Pharmaceutical Sciences, Shandong University
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- Xu Hongyan
- Institute of Pharmacology, Shandong University
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- Tian Shousheng
- Shandong Dong-E-E-Jiao Co., Ltd.
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- Zhang Yan
- Shandong Dong-E-E-Jiao Co., Ltd.
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- Zhang Jian
- School of Pharmaceutical Sciences, Shandong University
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- Wang Fengshan
- School of Pharmaceutical Sciences, Shandong University
Bibliographic Information
- Other Title
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- Effect of Colla corii asini (E'jiao) on D-Galactose Induced Aging Mice
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Abstract
Colla corii asini (E’jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks. Colla corii asini was simultaneously treated to them once daily by intragastric gavage. Appetite, mental condition, body weight, and organ index were observed. Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as levels of malondialdehyde (MDA) in serum, brain, and liver were determined by according assay kits. Western blotting analysis was used to detect p16 and p21 expression. Results indicated that Colla corii asini could improve appetite, mental condition, body weight, and organ condition of model mice, improve SOD, CAT, and GSH-Px activities, reduce MDA levels, and modulate age-related genes expression in D-gal induced mice. Therefore, Colla corii asini may have effect to suppress the aging process through enhancing antioxidant activity, scavenging free radicals, and modulating aging-related gene expression.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 35 (12), 2128-2132, 2012
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679610342528
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- NII Article ID
- 130002480501
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- NII Book ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3s7oslOltg%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 024105580
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- PubMed
- 23207764
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed