Viral Infection in Asthma

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  • Hashimoto Shu
    Division of Respiratory Medicine, Department of Medicine, Nihon University School of Medicine
  • Matsumoto Ken
    Division of Respiratory Medicine, Department of Medicine, Nihon University School of Medicine
  • Gon Yasuhiro
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences
  • Ichiwata Toshio
    Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital
  • Takahashi Noriaki
    Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital
  • Kobayashi Tomoko
    Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital

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Description

In bronchial asthma, respiratory virus infection involves several issues: 1) respiratory virus infection in infancy is a risk factor for, and may predispose to, the development of asthma later in life; 2) respiratory virus infection is associated with the acute exacerbation of bronchial asthma; and, 3) glucocorticosteroids (GC) are not adequate for controlling asthma-related symptoms upon respiratory virus infection. Various cells, inflammatory mediators and cytokines participate in the production of airway inflammation upon respiratory virus infection. Bronchial epithelial cells are a site of infection and replication of respiratory virus. They actively participate in the production of airway inflammation: 1) they produce various proinflammatory cytokines, chemokines and mediators; and, 2) they undergo apoptosis, thereby impairing the repair process. It is therefore important to understand the role of bronchial epithelial cells in the pathophysiology of bronchial asthma. In this review, the interaction between viral infection and asthma is discussed to elucidate the role of bronchial epithelial cells in viral infection.<br>

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