Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng
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- Lee Dae-Young
- Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA
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- Jeong Sang Chul
- HK BIO, Business Incubator, Daegu Haany University
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- Jeong Yong Tae
- HK BIO, Business Incubator, Daegu Haany University
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- Lee Mi-Kyoung
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University
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- Seo Kyeong-Hwa
- Department of Oriental Medicinal Materials and Processing, Kyung Hee University
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- Lee Jae-Won
- Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA
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- Kim Geum-Soog
- Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA
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- Lee Seung-Eun
- Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA
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- Baek Nam-In
- Department of Oriental Medicinal Materials and Processing, Kyung Hee University
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- Kim Jin Hee
- College of Herbal Bio-industry, Daegu Haany University
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Abstract
This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated from the leaves of P. ginseng C. A. MAYER and its chemical structure was determined based on spectroscopic methods, including FAB-MS, one-dimensional (1D)-NMR, 2D-NMR, and IR spectroscopy. Picrionoside A from P. ginseng has not been investigated previously, and its biological or pharmaceutical activities have not been reported elsewhere. The IC50 value of mushroom tyrosinase-inhibitory activity of picrionoside A was 9.8 µM, and the rate of inhibition of synthesized melanin content in melan-a cells was 17.1% at a concentration of 80 µM without cytotoxicity. Furthermore, picrionoside A dramatically reduced body pigmentation in the zebrafish model. Taken together, the results suggest that picrionoside A isolated from the leaves of P. ginseng may be an effective skin-whitening agent that could be a potent candidate material in the cosmetic industry.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 38 (10), 1663-1667, 2015
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679610884992
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- NII Article ID
- 130005101575
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 026763913
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- PubMed
- 26424028
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed