Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency : A Single-Dose, Double-Blind, 4-Way Crossover Study

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  • Morimoto Tatsuya
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
  • Sunagawa Yoichi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
  • Katanasaka Yasufumi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
  • Hirano Sae
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • Namiki Masatoshi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • Watanabe Yuichi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • Suzuki Hidetoshi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • Doi Osamu
    Shizuoka General Hospital
  • Suzuki Kiyomi
    Shizuoka General Hospital
  • Yamauchi Miyuki
    Shizuoka General Hospital
  • Yokoji Tsunehiro
    Shizuoka General Hospital
  • Miyoshi-Morimoto Eriko
    Shizuoka General Hospital
  • Otsuka Yoshihiko
    Theravalues Corporation
  • Hamada Tomoko
    Theravalues Corporation
  • Imaizumi Atsushi
    Theravalues Corporation
  • Nonaka Yuji
    Suntory Beverage & Food Limited
  • Fuwa Takashi
    Suntory Beverage & Food Limited
  • Teramoto Takanori
    Suntory Beverage & Food Limited
  • Kakeya Hideaki
    Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
  • Wada Hiromichi
    Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center
  • Hasegawa Koji
    Division of Translational Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center

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  • Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency—A Single-Dose, Double-Blind, 4-Way Crossover Study

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Curcumin has various biological activities including antioxidant and antiinflammatory actions, and alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to realize its bioactivities. We have generated capsules and tablets containing Theracurmin, a highly absorptive curcumin. In addition, we recently created a drinkable preparation of Theracurmin. To evaluate the absorption efficiency of this type of curcumin, we performed a single-dose, double-blind, 4-way crossover study. We compared plasma curcumin levels after the administration of Theracurmin beverage and 3 other drinkable types of curcumin sold in Japan. Twenty-four healthy subjects (male/female=13/11, age: 23–32) were administered with these 4 drinkable preparations of curcumin. The area under the blood concentration–time curve at 0–8 h was found to be 1.5 to 4.0-fold higher with Theracurmin than with the other 3 kinds of curcumin beverage. Moreover, maximal plasma curcumin concentrations (0–8 h) of Theracurmin were 1.8 to 3.8 times higher than those of the other 3 curcumin beverages. These data indicate that our newly prepared Theracurmin beverage exhibits a much better absorption efficiency than other kinds of curcumin beverage sold in Japan.

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