Effect of Carrageenan-Induced Acute Peripheral Inflammation on the Electrolyte Disposition to Cerebrospinal Fluid in Rats
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- Kono Kentaro
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- Okada Atsuyoshi
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- Ishikawa Atsuko
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- Aiba Tetsuya
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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To clarify whether peripheral inflammation has a remote effect on the central nervous system, the electrolyte disposition between the circulating blood and central nervous system was evaluated in rats with carrageenan-induced acute peripheral inflammation (API). λ-Carrageenan was subcutaneously injected in the hind paw of the rat, and lithium was utilized as a surrogate marker of sodium. When the plasma and cerebrospinal fluid (CSF) concentrations of lithium were examined following lithium being intravenously administered, it was revealed that the CSF concentration of lithium in API rats is reduced compared to that in normal rats, while the plasma concentration profile of lithium in API rats is indistinguishable from that in normal rats. The pharmacokinetic analysis showed that the lithium disposition from the plasma to CSF markedly decreased by 35.8% in API rats compared to that in normal rats. On the other hand, when lithium was immediately administered into the lateral ventricle, its elimination profiles in CSF were not different between normal and API rats. It is therefore probable that the lithium disposition from the plasma to CSF alters in API rats, reflecting the entry process of electrolytes from the circulating blood to brain tissue being suppressed in response to peripheral inflammation.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 36 (11), 1829-1834, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679611053440
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- NII論文ID
- 130003382049
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2c7ivFymtw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024957858
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- PubMed
- 24189427
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可