Highlighted Paper selected by Editor-in-Chief : Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops
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- Ito Yoshimasa
- Faculty of Pharmacy, Kinki University Pharmaceutical Research and Technology Institute, Kinki University
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- Nagai Noriaki
- Faculty of Pharmacy, Kinki University
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- Okamoto Norio
- Department of Ophthalmology, Kinki University Faculty of Medicine
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- Shimomura Yoshikazu
- Department of Ophthalmology, Kinki University Faculty of Medicine
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- Nakanishi Kunio
- Faculty of Pharmaceutical Science, Setsunan University
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- Tanaka Ryuichiro
- Faculty of Pharmaceutical Science, Setsunan University
書誌事項
- タイトル別名
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- Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops
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抄録
l-Pyroglutamic acid (PGA) is an endogenous molecule derived from l-glutamate. We demonstrate the effects of PGA on intraocular pressure (IOP) in experimentally induced ocular hypertension in rabbits. In the in vitro and in vivo transcorneal penetration studies, the PGA solution (PGA in saline) did not penetrate the rabbit cornea. On the other hand, the penetration of PGA was improved by the addition of zinc chloride and 2-hydroxypropyl-β-cyclodextrin (HPCD), and PGA penetration was enhanced with increasing HPCD concentration. Therefore, PGA solutions containing 0.5% zinc chloride and 5% or 10% HPCD (PGA/HPCD5% or 10% eye drops) were used to investigate the effects for IOP in this study. An elevation in IOP was induced by the rapid infusion of 5% glucose solution (15 mL/kg of body weight) through the marginal ear vein or maintaining under dark phase for 5 h. In the both models, the induced elevation in IOP was prevented by the instillation of PGA/HPCD eye drops, and the IOP-reducing effect enhanced with increasing HPCD concentration in the drops. Nitric oxide (NO) levels elevated in the aqueous humor following the infusion of 5% glucose solution, and this increase was also suppressed by the instillation of PGA/HPCD eye drops. In conclusion, the present study demonstrates that the instillation of PGA/HPCD eye drops has an IOP-reducing effect in rabbits with experimentally induced ocular hypertension, probably as a result of the suppression of NO production.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 36 (6), 1017-1023, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679611241216
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- NII論文ID
- 130003361452
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3snovFSjtw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024524457
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- PubMed
- 23727922
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可