書誌事項
- タイトル別名
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- Role of endothelin-1 and interleukin-6 immunoreactivity in infarcted area of human stroke.
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抄録
Recent descriptions of the identification of the vasoconstrictor peptide, endothelin-1 (ET-1), and inflammatory interleukin-6 (IL-6) have attracted much attention and excited speculation regarding their possible pathological significance in cerebral infarction. The present study focused on the expression of ET-1 and IL-6 in the human stroke brain in relation to the healing process of occlusive cerebrovascular disease. Eight patients with occlusive cerebrovascular disease were employed. For immunohistochemical studies on ET-1 and IL-6, polyclonal anti-human ET-1 antibody (Peptide Institute Inc., Japan) and polyclonal rabit antibody against human IL-6 (Genzyme, Boston) were used, respectively. In the stroke brain at the chronic phase of cerebrovascular accident, the immunohistochemical method demonstrated simultaneous production of both ET-1 and IL-6 associated with astrocyte proliferation in serial sections derived from the boundary area. In addition, the endothelial cells demonstrated strong staining for ET-1 as well as for IL-6. The percentages of ET-1 expression in the astrocytes and endothelium were 87.6 ± 12.8% and 93.2 ± 7.8%, respectively. IL-6 also exhibited simultaneous expression in both the astrocytes (92.9 ± 5.4%) and endothelium (90.0 ± 9.9%). ET-1 and IL-6 can thus be produced by both astrocytes and endothelium, and act on them in intercellular reactions. The presence of IL-6 immunoreactivity in the infarcted area is functionally linked with ET-1. Our data indicate that, although the precise order remains unknown, a sequence of immunologic events may play a role in the pathophysiology of human stroke.
収録刊行物
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- 脳卒中
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脳卒中 19 (2), 103-109, 1997
一般社団法人 日本脳卒中学会
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詳細情報 詳細情報について
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- CRID
- 1390282679614582784
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- NII論文ID
- 130003631260
- 10005236198
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- NII書誌ID
- AN0020186X
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- ISSN
- 18831923
- 09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可