書誌事項
- タイトル別名
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- Plasma thrombomodulin levels in cerebral thrombosis during the chronic stage.
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抄録
Thrombomodulin (TM) is a thrombin receptor on endothelial cells. Endothelial damage allows TM to be degraded and released into the blood stream. From this standpoint, we examined whether or not the plasma level of TM represents an endothelial cell marker which can reflect the endothelial damage associated with cerebral thrombosis. The plasma levels of TM were studied in age-matched healthy subjects and in cerebral thrombosis patients during the chronic stage with and without diabetes mellitus (DM). In the control, group, a significant correlation was noted between TM (Y) and age (X) as follows : Y = 0.190X + 8.299, r =0.718, p <0.01. The basal concentrations of TM were significantly elevated in the group with cerebral thrombosis (26.18 ± 12.000 U/ml) as compared to the controls (18.79 ± 4.43 U/ ml).<BR>Furthermore, among the patients with CVD, those with DM showed higher levels of TM (34.85 ± 21.03 U/ml) than those without DM (23.73 ± 6.31 U/ml). Thus, high TM levels could well reflect the presence of endothelial damage. In conclusion, the level of TM in the plasma is considered to be a potential marker of the presence of endothelial injury associated with cerebral thrombosis.
収録刊行物
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- 脳卒中
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脳卒中 18 (2), 98-103, 1996
一般社団法人 日本脳卒中学会
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詳細情報 詳細情報について
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- CRID
- 1390282679614910208
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- NII論文ID
- 130003438972
- 10009405106
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- NII書誌ID
- AN0020186X
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- ISSN
- 18831923
- 09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可