Interaction between endothelin-1 and noradrenalin in human stroke.

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  • 脳出血におけるＥｎｄｏｔｈｅｌｉｎ－１とＮｏｒａｄｒｅｎａｌｉｎ作動　神経系の相互作用について

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Endothelin-1 (ET-1) is a recently identified 21-amino acid peptide produced by the vascular endothelium and is the most potent known vasoconstrictor. The present study attempted to evaluate the interaction between the level of ET-1 and the concentration of noradrenalin in the plasma over a period of 2 weeks following an episode of cerebral hemorrhage. Thirty-seven patients with cerebral hemorrhage were examined. We estimated the immunoreactive ET-1 by radioimmunoassay. The level of ET-1 during the acute stage (day 7) was 4.03 ± 1.32 pg/ml, which was significantly higher than that (2.03± 1.38 pg/ml) during the subacute stage (day 8 to day 14). During the acute stage, a close relationship existed between the ET-1 (X) and noradrenalin (Y). Linear regression analysis yielded the following equation : Y= 148.62X -18.38 (r = 0.555, p <0.01). Also, during the subacute stage, the increase in level of ET-1 (X) with noradrenalin (Y) revealed an excellent linear relationship (Y=251.1X + 196.08; r = 0.867, p<0.01). These linear regressions obtained during the acute stage and during the subacute stage displayed a significant difference (p < 0.01). In conclusion, the time course of interaction between ET-1 and noradrenalin may be closely related to the functional sequence of derangement of both the endothelium and noradrenalin nervous system.

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