脳内細動脈外膜肥厚の部位的検討　白質と基底核，視床での差異

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タイトル別名
  • Regional differences in adventitial proliferation of the cerebral arterioles. Comparison of the white matter, basal ganglia and thalamus.
  • Comparison of the white matter, basal ganglia and thalamus
  • 白質と基底核, 視床での差異

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Ischemic lesions in the cerebral white matter tend to be asymptomatic and to be detected before the onset of symptomatic cerebral infarction. Lesions in the basal ganglia or thalamus, on the other hand, are more frequently symptomatic. We conducted a pathological study on 111 autopsied specimens to evaluate the arteriolosclerotic changes in these areas. The type of arteriolosclerosis common to all areas was fibrotic adventitial proliferation, being most advanced in the white matter and progressing with age. When compared to the controls, patients with lacunar infarction in the basal ganglia or thalamus had advanced arteriolosclerosis not only in those areas but also in the white matter. The degree of arteriolar adventitial proliferation in the white matter was significantly correlated with that in the basal ganglia in the controls and cases of lacunar infarction. It is concluded that arteriolar adventitial proliferation may be an indicator of progressive ischemia in the brain. Since arteriolosclerosis in the white matter precedes that in other areas, it would appear that asymptomatic lesions in the white matter are followed by symptomatic ones.

収録刊行物

  • 脳卒中

    脳卒中 18 (3), 170-175, 1996

    一般社団法人 日本脳卒中学会

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