脳血管障害における髄液Ｅｎｄｏｔｈｅｌｉｎ‐３について

DOI 被引用文献2件 参考文献19件

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  • Endothelin-3 concentration in cerebrospinal fluid following cerebrovascular disease.

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Endothelin-1 (ET-1) has been shown to be a vasconstrictor peptide related to the function of the endothelium, but the site of ET-3 synthesis has not yet been determined. No systematic evaluation of ET-3 has ever been attempted during the acute stage of cerebrovascular disease (CVD). We determined the ET-3 concentrations of the cerebrospinal fluid (CSF) in CVD. The subjects comprised 15 patients including 7 cases with hemorrhagic CVD and 8 cases with occlusive CVD. We found that the CSF level of ET-3 on day 1 (68.9 ± 21.4 pg/ml) was significantly increased in hemorrhagic CVD as compared to that on day 14 (57.6 ± 7.1 pg/ml). Occlusive CVD also demonstrated a higher level of ET-3 on day 1 (54.8 ± 9.8 pg/ ml), followed by a substantial decrease on day 14 (47.0± 6.8 pg/ml). The value on day 1 was significantly higher than that on day 14. In addition, patients who underwent repeated measurement of the ET-3 in their CSF showed a gradeal decrease in ET-3 throughout the study (on day 1, day 14 and day 28). We have reported that elevated concentrations of ET-1 in both the plasma and CSF were noted during the acute stage of CVD in a previous study. Thus, the ET-3 concentration in the CSF is thought to increase in association with a raised concentration of ET-1. Considering its potent vasodilator effect, ET-3 may play an important role in the pathophysiology of CVD.

収録刊行物

  • 脳卒中

    脳卒中 18 (3), 193-199, 1996

    一般社団法人 日本脳卒中学会

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