Characterization of digestive enzyme formulas available in Japan and how each digestive enzyme formula ought to be prescribed to patients with pancreatic diseases in different conditions

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  • B.H.KO Shigeru
    Department of Systems Medicine, Keio University School of Medicine

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  • 我が国で処方可能な各種消化酵素製剤の特長とそれに応じた製剤の使い分け

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Abstract

<p>Humans do not produce nutrients by themselves. To live, meat and vegetables have to be ingested as food and digested in the gastrointestinal tract so that nutrients are absorbed through the intestinal epithelium. As the secretion of digestive enzymes is more or less impaired in most of the patients with pancreatic diseases, digestive enzyme replacement therapies are often required. Digestive enzyme formulas are a mixture of digestive enzymes extracted from microorganisms and porcine pancreas, pancreatin. The optimum pH is alkaline for the activity of pancreatin, but neutral to acidic for microorganism-derived digestive enzymes, adapted to the small intestine and the stomach environment, respectively. Each digestive enzyme formula is optimized for different pH ranging from acidic to alkaline, but little is known about the characteristics of each enzyme formula.</p><p>In this article, we illustrate differences of assays to evaluate the enzymatic activity of digestive enzymes in Japanese and European pharmacopoeia and characterize each digestive enzyme formula based on our previous study. We then discuss how to best prescribe each digestive enzyme formula to different patient conditions.</p>

Journal

  • Suizo

    Suizo 32 (2), 125-139, 2017

    Japan Pancreas Society

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