A case of cerebral infarction associated with idiopathic thrombocytopenic purpura and anti-cardiolipin antibody.

DOI

Bibliographic Information

Other Title
  • 抗カルジオリピン抗体陽性の特発性血小板減少性紫班病に脳梗塞を合併した１症例

Abstract

A 54-year-old man was admitted to our hospital complaining of clumsiness of right hand and dysarthria. Neurological examination revealed moderate weakness of the right upper extremities with mild sensory aphasia, agraphia, and alexia. The CT scan of the brain disclosed a low-density area around the left angular gyrus, and the cerebral angiography showed moderate stenosis of M1 portion of the left middle cerebral artery. The diagnosis of brain infarction was made.<BR>No hemorrhagic tendency was clinically observed, but thrombocytepenia with normal bone marrow persisted. Platelet associated IgG was increased so that the association of idiopathic thrombocytepenic purpura (ITP) was diagnosed.<BR>The platelet aggregation induced by ADP, arachidonic acid, and epinephrin was all decreased. The serologic test for syphilis was false-positive and serum anti-cardiolipin antibody was found. Other abnormalities in coagulation and fibrinolysis and autoantibodies could not be detected.<BR>We speculate that anti-cardiolipin antibody contributed to cause cerebral infarction through immunological process in the circumstances of thrombocytopenia due to ITP.

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Details 詳細情報について

  • CRID
    1390282679616695424
  • NII Article ID
    130003630992
  • DOI
    10.3995/jstroke.14.402
  • ISSN
    18831923
    09120726
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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