A case of pleomorphic anaplastic carcinoma of the pancreas responding to gemcitabine+nab-paclitaxel therapy

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  • TOMISHIMA Ko
    Department of Gastroenterology, Juntendo University School of Medicine
  • FUJISAWA Toshio
    Department of Gastroenterology, Juntendo University School of Medicine
  • KANAZAWA Ryo
    Department of Gastroenterology, Juntendo University School of Medicine
  • MIURA Hiroko
    Department of Gastroenterology, Juntendo University School of Medicine
  • ISHII Shigeto
    Department of Gastroenterology, Juntendo University School of Medicine
  • ITO Tomoyasu
    Department of Gastroenterology, Juntendo University School of Medicine
  • SAITO Hiroaki
    Department of Gastroenterology, Juntendo University School of Medicine
  • FUKUMURA Yuki
    Department of Human Pathology, Juntendo University School of Medicine
  • SHIINA Shuichiro
    Department of Gastroenterology, Juntendo University School of Medicine
  • WATANABE Sumio
    Department of Gastroenterology, Juntendo University School of Medicine

Bibliographic Information

Other Title
  • Gemcitabine+nab-paclitaxelにて腫瘍縮小傾向を認めた多形細胞型退形成膵管癌の一例

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Description

<p>Contrast-enhanced CT of a 49-year-old woman with back pain revealed a low-density tumor in the pancreas head and multifocal liver metastases. Endoscopic ultrasonography-guided fine needle aspiration of the tumor led to the diagnosis of anaplastic carcinoma of the pancreas. The patient was referred to our hospital for chemotherapy. A combination therapy with 80% doses of gemcitabine and nab-paclitaxel was administered. Follow-up CT after the chemotherapy showed slight reduction of the primary pancreatic tumor and remarkable reduction of liver metastases. Three months after introduction of the chemotherapy, however, the combination therapy had to be changed to monotherapy with S-1 due to appetite loss and decreasing activity of daily living. The patient died four months after the first visit due to general prostration. Autopsy revealed pleomorphic anaplastic carcinoma of the pancreas. Pleomorphic anaplastic pancreas carcinoma is a rare and highly virulent condition, and above all, there have been almost no reported cases that have showed any response to chemotherapy. The partial response described in this report would be instructive in deciding treatment strategy for unresectable pleomorphic anaplastic carcinoma of the pancreas.</p>

Journal

  • Suizo

    Suizo 32 (5), 812-820, 2017

    Japan Pancreas Society

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