The history of Granulocyte-colony stimulating factor

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Other Title
  • G―CSF製剤の歴史
  • G-CSF セイザイ ノ レキシ

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Description

Granulocyte-colony stimulating factor is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Pegylated G-CSF(pegfilgrastim), in which the addition of polyethylene glycol increases the half-life of the agent, decreases the incidence of febrile neutropenia during chemotherapy. The use of G-CSF support is also important to increase dose intensity or dose density of chemotherapy. Pegylated materials are expected to play an important role in cancer treatment.

Journal

  • Drug Delivery System

    Drug Delivery System 32 (2), 134-142, 2017

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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