書誌事項
- タイトル別名
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- Evaluation of acute toxicity of epirubicin hydrochloride-encapsulating w/o/w emulsion administered to rat for the transcatheter embolization therapy for hepatocellular carcinoma.
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説明
The toxicity of lipiodol (LPD) w/o/w emulsions encapsulating epirubicin hydrochloride (FARM) after iv administration to rat was investigated compared to the conventional o/w emulsions used for transcathether arterial embolization (TAE) therapy for hepatocellular carcinoma. Survival time of the rat administered w/o/w emulsion was longer than that of the o/w emulsion. The rats administered o/w emulsion (≥1.5 ml/kg) were deceased within 2 days by pulmonary edema caused by embolism with fine oil droplets. The edema was not found in the lungs of the rats administered w/o/w emulsion. The toxicity of the FARM, ie, size reduction of thymus gland and ulceration in the stomach, was reduced by encapsulating the drug in the w/o/w emulsion. The present w/o/w emulsion prepared by us proved a desirable formulation for the TAE therapy because of reducing toxicities of oil droplets and drug.
収録刊行物
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- Ｄｒｕｇ Ｄｅｌｉｖｅｒｙ Ｓｙｓｔｅｍ
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Ｄｒｕｇ Ｄｅｌｉｖｅｒｙ Ｓｙｓｔｅｍ 12 (3), 161-165, 1997
日本DDS学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679617871488
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- NII論文ID
- 10007337400
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- NII書誌ID
- AN10084591
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- ISSN
- 18812732
- 09135006
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可