Transdermal vaccine delivery system(TVDSs)

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  • Ohmori Naoya
    Department of Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Josai International University
  • Goto Takeshi
    Department of Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Josai International University
  • Sato Shuji
    Department of Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Josai International University

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Other Title
  • 経皮ワクチンデリバリーシステム
  • ケイヒ ワクチンデリバリー システム

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Abstract

Transdermal vaccines utilizing skin immune function are considered a promising modality to administer vaccines because of their less invasiveness than vaccine administration by injection, of their high safety, and of their simplicity in transport and storage. Furthermore, transdermal vaccines allow the optimization of preparations for each antigen because Th1/Th2 immune responses can be adjusted by skin pretreatment or adjuvant selection. Currently, transdermal vaccine delivery systems (TVDSs) are driven for the optimization of adjuvants and for the development of physical methods to administer antigens. Clinical trials of some systems are ongoing, and TVDSs are now the technologies that are promising also in preventive medicine.

Journal

  • Drug Delivery System

    Drug Delivery System 22 (4), 468-475, 2007

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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