Species difference of drug metabolism: difficulty of prediction of drug disposition in human from animal data

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  • Imai Teruko
    Faculty of Pharmaceutical Sciences, Kumamoto University

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Other Title
  • 日本のトランスレーショナルリサーチをどう進めるか　　薬物代謝の動物種差―動物のデータはヒトにどこまで迫れるか―
  • 薬物代謝の動物種差--動物のデータはヒトにどこまで迫れるか
  • ヤクブツ タイシャ ノ ドウブツ シュサ ドウブツ ノ データ ワ ヒト ニ ドコ マデ セマレル カ
  • difficulty of prediction of drug disposition in human from animal data
  • 動物のデータはヒトにどこまで迫れるか

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Abstract

In the process of drug development, animal experiments are inevitable but may not reflect accurately the human conditions due to species difference in drug disposition, especially metabolism. In this paper, species differences in drug metabolizing enzymes and a method to predict human pharmacokinetics are explained.

Journal

  • Drug Delivery System

    Drug Delivery System 22 (1), 48-53, 2007

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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