Imaging technology for the research and the development of DDS nanocarriers and nanomedicines

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  • Urakami Takeo
    Department of Medical Biochemistry and Global COE, University of Shizuoka Graduate School of Pharmaceutical Sciences
  • Oku Naoto
    Department of Medical Biochemistry and Global COE, University of Shizuoka Graduate School of Pharmaceutical Sciences

Bibliographic Information

Other Title
  • 分子イメージングとＤＤＳ　　ＤＤＳ製剤開発のためのイメージング技術
  • DDS製剤開発のためのイメージング技術
  • DDS セイザイ カイハツ ノ タメノ イメージング ギジュツ

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Description

Biological imaging techniques have been advanced with the development of imaging systems and corresponding imaging probes. Among the systems, positron emission tomography(PET), an imaging system by using extremely short half-life positron-emitters, is considered as one of the most sensitive imaging modality. PET has been used for functional imaging in clinical diagnostic field as well as that in research purpose. In vivo molecular imaging of the drug candidates can be used for the analysis of their distribution properties in a living body. To accelerate the development of DDS mediated medicines, in vivo imaging technology for determining the behavior of nanoparticles and for nanomedicines would be useful.<BR>We have studied on the trafficking of various kinds of liposomes by use of PET, and, recently, we have developed a rapid and easy positron-labeling methodology for DDS nanoparticles. In this review, we introduce the modality of in vivo molecular imaging for the development of DDS medicine and discuss the prospects of the technology.

Journal

  • Drug Delivery System

    Drug Delivery System 23 (1), 40-48, 2008

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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