Drug delivery system in hormonal agents: long-term release LH-RH agonist

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Other Title
  • 臨床応用されているＤＤＳ　　ホルモン製剤のＤＤＳ　　（ＬＨ‐ＲＨアゴニストの徐放性製剤）
  • Drug delivery system in hormonal agents : long-term release LH-RH agonist
  • ホルモン製剤のDDS(LH-RHアゴニストの徐放性製剤)

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Abstract

Leuprorelin (leuprolide) acetate, a highly active agonist of luteinizing hormone-releasing hormone (LH-RH) has been widely accepted as a representative agent utilizing drug delivery system. A single injection of this one-month or three-month depot provides persistent drug release, which has been applied to therapy in patients with prostate cancer, breast cancer, endometriosis, myoma uteri, and central precocious puberty. The profile of this drug from basic research to clinical application was reviewed.

Journal

  • Drug Delivery System

    Drug Delivery System 18 (5), 431-437, 2003

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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