Inorganic phosphate homeostasis: crosstalk between kidney and other organs

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  • Tatsumi Sawako
    Department of Molecular Nutrition Institute of Health Biosciences, The University of Tokushima Graduate School
  • Kaneko Ichiro
    Department of Molecular Nutrition Institute of Health Biosciences, The University of Tokushima Graduate School
  • Segawa Hiroko
    Department of Molecular Nutrition Institute of Health Biosciences, The University of Tokushima Graduate School
  • Miyamoto Kenichi
    Department of Molecular Nutrition Institute of Health Biosciences, The University of Tokushima Graduate School

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Other Title
  • 生体内リン恒常性維持機構―多臓器連関制御
  • セイタイナイ リン コウジョウセイ イジ キコウ : タゾウキ レンカン セイギョ

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Abstract

Inorganic phosphate (Pi) is an essential nutrient for several biological functions, including intracellular signal transduction, the production and function of cell membranes, and energy exchange. The maintenance of constant circulating levels of Pi depends on the coordinated activity of three major organs: the intestine, the kidney, and the bones. To achieve these functions, a transport system is required to transfer Pi across hydrophobic cell membranes. Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D3 are also regulators of Pi homeostasis, and recent studies have identified other factors that contribute to the maintenance of Pi homeostasis, including first phosphatonins [fibroblast growth factor (FGF) 23] originated from osteocytes established the concept of the bone-kidney axis. In this review, we discuss Pi homeostasis through several tissues.

Journal

  • Drug Delivery System

    Drug Delivery System 29 (5), 408-416, 2014

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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