Tumor- and Immune Cell-Derived Exosomes

DOI Web Site 1 Citations 59 References
  • Seo Naohiro
    Department of Cancer Vaccine,Mie University Graduate School of Medicine
  • Shiku Hiroshi
    Department of Cancer Vaccine,Mie University Graduate School of Medicine

Bibliographic Information

Other Title
  • 癌と免疫とエクソソーム
  • ガン ト メンエキ ト エクソソーム

Search this article

Description

There are a few reports about the role of exosomes released from anti-tumor immune cells including T cells, NK cells, DCs or macrophages. On the other hand, it has been clarified that tumor cell-derived exosomes play a crucial role in the formation of tumor microenvironment and epithelial-mesenchymal transition (EMT) of tumors by cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) under the effect of exosomal microRNAs (miRs) and proteins. In addition, tumor-derived exosomes have been reported to attenuate tumoricidal immune responses. In this review, we describe the possibility of exosome-based tumor immunotherapy followed by understanding biological significances of immune cell- and tumor cell-derived exosomes.

Journal

  • Drug Delivery System

    Drug Delivery System 29 (2), 152-159, 2014

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Citations (1)*help

See more

References(59)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top