書誌事項
- タイトル別名
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- Single Cell Control Based on Femtosecond Laser-induced Nonlinear Phenomena
- シュウコウ フェムトビョウ レーザー ガ ユウキスル ショゲンショウ オ リヨウシタ サイボウ セイギョ ギジュツ
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抄録
When a near-infrared (NIR) femtosecond laser is focused in water, several kinds of nonlinear phenomena, such as shockwave propagation, cavitation bubble generation, and jet flow, are induced in the vicinity of the laser focal point. Such phenomena are also induced by near-infrared nanosecond and picosecond lasers, but femtosecond irradiation allows a better localization. Moreover NIR femtosecond laser focussing permits to perform a local processing of cell and tissue because of its efficient multi-photon absorption and photo-mechanical ablation mechanism. In this study, the impulsive force generated in cell culture medium by these nonlinear phenomena was applied to individual control of single animal cells. Mouse NIH-3T3 fibroblast cells cultured on a substrate were independently isolated by the impulsive force, and patterned by transferring them to another substrate. Furthermore nanoparticles and biological molecules are transfected to the cell by the local processing of the cell membrane. These demonstrations are promising for future femtosecond laser methodology for bioscience and biotechnology.
収録刊行物
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- レーザー研究
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レーザー研究 35 (7), 430-435, 2007
一般社団法人 レーザー学会
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詳細情報 詳細情報について
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- CRID
- 1390282679623301632
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- NII論文ID
- 10019524725
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- NII書誌ID
- AN00255326
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- COI
- 1:CAS:528:DC%2BD2sXptlaqs7o%3D
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- ISSN
- 13496603
- 03870200
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- NDL書誌ID
- 8896226
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可