Detection of immune complexes by monoclonal anti-C1q and anti-C3d ELISA systems.

DOI Web Site 3 Citations
  • Kazuo Watanabe
    The Second Department of Internal Medicine, Fukushima Medical College
  • Hiroshi Watanabe
    The Second Department of Internal Medicine, Fukushima Medical College
  • Satomi Kida
    The Second Department of Internal Medicine, Fukushima Medical College
  • Hiroshi Funabashi
    The Second Department of Internal Medicine, Fukushima Medical College
  • Yoshimitsu Ohkubo
    The Second Department of Internal Medicine, Fukushima Medical College
  • Yukio Satoh
    The Second Department of Internal Medicine, Fukushima Medical College
  • Masayuki Miyata
    The Second Department of Internal Medicine, Fukushima Medical College
  • Shunji Kaise
    The Second Department of Internal Medicine, Fukushima Medical College
  • Tomoe Nishimaki
    The Second Department of Internal Medicine, Fukushima Medical College
  • Takao Moritoh
    The Second Department of Internal Medicine, Fukushima Medical College
  • Reiji Kasukawa
    The Second Department of Internal Medicine, Fukushima Medical College

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  • 抗Ｃ１ｑ抗体法および抗Ｃ３ｄ抗体法のＥＬＩＳＡキットを用いた血中免疫複合体測定の臨床的検討

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By means of monoclonal anti-C1q and anti-C3d ELISA systems, circulating immune complexes (CIC) of patients with various collagen diseases were measured.<br>The positive frequencies and mean values of CIC detected by anti-C1q were 94% and 145.8μg/ml in active SLE, 50% and 52.5μg/ml in inactive SLE and 56.8% and 58.5μg/ml in RA.<br>On the other hand, CIC detected by anti-C3d were 67% and 20.0μg/ml in active SLE, 14% and 2.7μg/ml in inactive SLE and 21.6% and 6.1μg/ml in RA.<br>Levels of CIC detected by the both systems correlated positively with titers of anti-DNA antibodies and negatively with titers of serum CH50 in SLE.<br>In RA, levels of CIC detected by anti-C3d correlated positively with ESR and CRP, whereas those by anti-C1q did not. No correlations between levels of CIC detected by the both systems and titers of RF were observed.

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