書誌事項
- タイトル別名
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- Inhibitory effect of iron on Fc- and C3-receptor expression of human monocytes.
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抄録
The effects of iron and iron-binding proteins on Fc- and C3-receptor function of human monocytes were examined. Human peripheral blood monocytes were obtained as adherent cells on a cover glass after isolation of peripheral blood mononuclear cells (PBMC) from heparinized venous blood by Conray-Ficoll gradients. Human O type red cells coated with anti-D antibody (IgG) or with third complement component were used as indicator cells for EA or EC rosette formation. The co-culture of human monocytes with 1mM concentration of ferric citrate for 7 days but not for 1 hour gave rise to the significant decrease of both Fc- and C3-receptor function of the cells. None of the other concentrations of ferric citrate (0.01, 0.1mM) and iron-binding proteins (transferrin and lactoferrin, 10-6M) had any effect on both of receptor function of monocytes cultured for 1 hour or 7 days.
収録刊行物
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- 日本臨床免疫学会会誌
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日本臨床免疫学会会誌 12 (2), 202-208, 1989
日本臨床免疫学会
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詳細情報 詳細情報について
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- CRID
- 1390282679625341184
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- NII論文ID
- 130000850975
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- ISSN
- 13497413
- 09114300
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可