-
- Mizoguchi Yasuhiro
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- Sakagami Yoshihide
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- Seki Shuichi
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- Kobayashi Kenzo
- The Third Department of Internal Medicine, Osaka City University Medical School
-
- Yamamoto Sukeo
- The Osaka Socio-Medical Center Hospital
-
- Morisawa Seiji
- The First Department of Biochemistry, Osaka City University Medical School
Bibliographic Information
- Other Title
-
- 免疫学的急性肝不全誘導マウスにおけるトリプトファン代謝について
Search this article
Abstract
Massive hepatic cell necrosis can be induced in mice by an intravenous injection of Propionibacterium acnes (P. acnes) followed by an intravenous injection of a small mount of lipopolysaccharide (LPS) 7 days later. Using this experimentally-induced acute hepatic failure model, the products of tryptophan (TRP) metabolism during hepatocytotoxicity were studied. As a result, in acute hepatic failure-induced mice, blood indoleacetic acid (IAA) level increased before the increase in serum transaminase level, and its peak was seen 21 hours before that of transaminase. In addition, when hepatic cells separated from the mice were loaded with TRP and cultured with the cytotoxic factor produced from activated liver adherent cells, IAA level of the hepatic cells increased remarkably.<br>These results suggest that during hepatocytotoxicity, the change from kynurenine to nicotinamide by the major pathway of TRP metabolism may be inhibited, and that the pathway from TRP to tryptamine to IAA may be impaired.
Journal
-
- Japanese Journal of Clinical Immunology
-
Japanese Journal of Clinical Immunology 11 (4), 377-383, 1988
The Japan Society for Clinical Immunology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679625702656
-
- NII Article ID
- 130000850865
-
- ISSN
- 13497413
- 09114300
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed