A case of pseudoscleroderma as paraneoplastic syndrome due to carcinoma of cervical uteri

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  • YAMAMOTO Motohisa
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • SUZUKI Chisako
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • NAISHIRO Yasuyoshi
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • TSUKUDA Hiroyuki
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • MURAKAMI Rieko
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • YAMAMOTO Hiroyuki
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • TAKAHASHI Hiroki
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine
  • IMAI Kohzoh
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine

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  • 強皮症様病態を呈したｐａｒａｎｅｏｐｌａｓｔｉｃ　ｓｙｎｄｒｏｍｅの１例

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Abstract

A 65-year-old female began experiencing arthralgia, morning stiffness and psychroesthesia in April 2000. She visited a rheumatologist and was suspected of having early-stage rheumatoid arthritis. She was referred to our hospital, and was admitted in December 2000. At that time, sclerosis of the skin was advanced, and Raynaud's phenomenon was confirmed. The patient also exhibited nailfold bleeding, and was diagnosed as having systemic scleroderma. She visited a gynecologist for screening and cervical uteri carcinoma was confirmed. She underwent surgery in March 2001, and subsequently, sclerosis in her skin was almost stopped. We believe that these clinical symptoms were related to paraneoplastic syndrome. We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that connective tissue growth factor (CTGF) might be involved and transforming growth factor-β (TGF-β) might not be involved in this case.

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