Analyses of Aqueductal Area and Cerebrospinal Fluid Flow-Velocity in Normal Pressure Hydrocephalus

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  • HIRAMATSU Yuki
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • MIYATI Tosiaki
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • MASE Mitsuhito
    Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University
  • OHNO Ｎaoki
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

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Other Title
  • 正常圧水頭症における中脳水道の断面積と脳脊髄液拍動速度の解析

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<p>In this study, we assessed cross-sectional area of the aqueduct and the cerebrospinal fluid（CSF）flow-velocity in normal pressure hydrocephalus（NPH）using cine magnetic resonance imaging（MRI）. On a 1.5-T MRI, ECG-synchronized phase-contrast cine-MRI technique was used to measure the quantitative CSF flow-velocity in the aqueduct in patient with NPH（n=24）, atrophic ventricular dilation（VD,n=19）and healthy volunteers（control, n = 25）. The aqueductal area was measured using high-resolution T2-weighted image in each group. The aqueductal CSF flow-velocity amplitude was significantly larger in the NPH group（19.68 ± 10.98 cm/s）than in the VD group（6.67 ± 3.88, P < 0.001）and the control group（10.98 ± 4.26, P = 0.018）. The aquedutal area was significantly lager in the NPH group（0.08 ± 0.04 cm2）than in the control group（0.03 ± 0.01, P < 0.001）, but not significantly different between the NPH and VD groups（0.08 ± 0.05, P = 1.000）. Aqueductal CSF flow-velocity in NPH increases, despite the aqueductal area increases.</p>

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