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The pathogenesis of ANCA-associated vasculitis
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- ISHIZU Akihiro
- Faculty of Health Sciences, Hokkaido University
Bibliographic Information
- Other Title
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- ANCA関連血管炎の病態メカニズム
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Description
<p> ANCA-associated vasculitis is characterized by the presence of anti-neutrophil cytoplasmic antibody (ANCA) in the serum. ANCA is a pathogenic autoantibody as well as the disease marker. It has been realized that ANCA-cytokine sequence is involved in the pathogenesis of ANCA-associated vasculitis. Recent studies have revealed that neutrophil extracellular traps induced by ANCA are also involved in the pathogenesis. In this study, we review the roles of neutrophils, eosinophils, macrophages/dendritic cells, complements, B cells/plasma cells, T cells, and cytokines/chemokines/cell growth factors in the pathogenesis of ANCA-associated vasculitis.</p>
Journal
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- Japanese Journal of Clinical Immunology
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Japanese Journal of Clinical Immunology 39 (6), 491-496, 2016
The Japan Society for Clinical Immunology
