Successful early treatment in a case of Cogan's syndrome

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  • TSUNO Hirotaka
    Division of Rheumatic Diseases National Center for Global Health and Medicine
  • TAKAHASHI Yuko
    Division of Rheumatic Diseases National Center for Global Health and Medicine
  • YOSHIDA Yuji
    Division of Rheumatic Diseases National Center for Global Health and Medicine
  • ARAI Naotoshi
    Department of Neurology, National Center for Global Health and Medicine
  • NAKAMURA Yousuke
    Department of Ophthalmology, National Center for Global Health and Medicine
  • YASHIRO Seiko
    Department of Ophthalmology, National Center for Global Health and Medicine
  • MAKIZUMI Masami
    Department of Otolaryngology•head and neck surgery, National Center for Global Health and Medicine
  • YAMASHITA Hiroyuki
    Division of Rheumatic Diseases National Center for Global Health and Medicine
  • KANEKO Hiroshi
    Division of Rheumatic Diseases National Center for Global Health and Medicine
  • KANO Toshikazu
    Division of Rheumatic Diseases National Center for Global Health and Medicine
  • MIMORI Akio
    Division of Rheumatic Diseases National Center for Global Health and Medicine

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Other Title
  • 早期治療介入により寛解の得られたCogan症候群の1例

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  We report a 53-year-old male with Cogan's syndrome. He was admitted to our hospital because of a fever of 2-weeks duration, blurred vision for 10 days, hypoacusis, and numbness of the left hand for 3 days. In addition to uveitis, hypoacusis, and aseptic meningitis, multiple mononeuropathy was diagnosed based on a nerve conduction study. Furthermore, positron emission tomography/computed tomography (PET/CT) revealed diffuse aortitis. Accordingly, the patient was diagnosed with Cogan's syndrome. After starting steroid-pulse therapy followed by 1 mg oral prednisolone/kg/day, the uveitis and hypoacusis improved immediately, while the peripheral neuropathy persisted until effectively treated with intravenous gamma globulin therapy. Prompt steroid therapy for Cogan's syndrome based on a diagnosis made using PET/CT prevented progression of the hypoacusis.<br>

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