Development of Magnetic Particle Imaging and Application to Nanomedicine

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  • MURASE Kenya
    Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine

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  • 磁気粒子イメージング法の開発とナノ医学への応用

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<p>Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines. In 2005, a new imaging method called magnetic particle imaging （MPI）was introduced. MPI can visualize the spatial distribution of magnetic nanoparticles（MNPs）with high sensitivity, spatial resolution, and imaging speed. MPI uses the nonlinear response of MNPs to detect their presence in an alternating magnetic field（AMF）. MNPs can induce heat under an AMF, which allows applications to hyperthermia（magnetic hyperthermia）. This paper describes the principle of MPI and applications to nanomedicine including the quantification of pulmonary mucociliary clearance, the prediction of therapeutic effects of magnetic hyperthermia, the monitoring of magnetic targeting, and cellular imaging and tracking for regenerative medicine. The future perspective of MPI is also described.</p>

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