Psoriasiform eruption induced by adalimumab in a patient with rheumatoid arthritis : a case report and review of literature
-
- KUNO Haruna
- Department of Internal Medicine (I), Osaka Medical College
-
- KOTANI Takuya
- Department of Internal Medicine (I), Osaka Medical College
-
- TAKEUCHI Tohru
- Department of Internal Medicine (I), Osaka Medical College
-
- WAKURA Daisuke
- Department of Internal Medicine (I), Osaka Medical College
-
- WAKURA Reiko
- Department of Internal Medicine (I), Osaka Medical College
-
- YU Akitoshi
- Department of Dermatology, Osaka Medical College
-
- MAKINO Shigeki
- Department of Internal Medicine (I), Osaka Medical College
-
- MORIWAKI Shinichi
- Department of Dermatology, Osaka Medical College
-
- HANAFUSA Toshiaki
- Department of Internal Medicine (I), Osaka Medical College
Bibliographic Information
- Other Title
-
- アダリムマブ治療中に乾癬様皮疹を生じた関節リウマチの一例
Search this article
Abstract
A 72-year-old man developed arthritis of the bilateral shoulders and fingers. X-ray examination of the fingers showed periarticular osteoporosis, joint space narrowing, and cystic changes at the bone ends. Because contrast-enhanced MRI revealed synovial membrane proliferation and osteolysis, a diagnosis of rheumatoid arthritis (RA) was made. Treatment for RA with methotrexate (4 mg/week) was initiated in December 2008. In February 2009, adalimumab administration (40 mg/2 weeks) was initiated. The RA markedly improved, and clinical remission was maintained thereafter. However, in April 2010, relatively well-delineated erythematous plaques accompanied by bullae and scales developed on the bilateral palms, toes, limbs, and the inguinal region. A diagnosis of psoriasis-like eruptions was made by skin biopsy, and adalimumab administration was discontinued. After 4 months, the eruptions improved. Psoriasis-like eruptions due to anti-TNF drugs are rarely observed, but adverse effects require caution. This case is reported along with a review of the literature.<br>
Journal
-
- Japanese Journal of Clinical Immunology
-
Japanese Journal of Clinical Immunology 35 (6), 520-525, 2012
The Japan Society for Clinical Immunology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679630389376
-
- NII Article ID
- 10031147896
-
- NII Book ID
- AN00357971
-
- COI
- 1:STN:280:DC%2BC3s3mvFyisQ%3D%3D
-
- ISSN
- 13497413
- 09114300
-
- PubMed
- 23291487
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed