Automated measurement method of bone mineral density of vertebral bones and spinal curvature using sagittal plane in X-ray torso CT images

DOI IR HANDLE
  • HAN Mingxu
    Department of Intelligent Image Information, Graduate School of Medicine, Gifu University
  • HAYASHI Tatsuro
    Department of Intelligent Image Information, Graduate School of Medicine, Gifu University
  • ZHOU Xiangrong
    Department of Intelligent Image Information, Graduate School of Medicine, Gifu University
  • CHEN Huayue
    Department of Anatomy, Graduate School of Medicine, Gifu University
  • HARA Takeshi
    Department of Intelligent Image Information, Graduate School of Medicine, Gifu University
  • FUJITA Hiroshi
    Department of Intelligent Image Information, Graduate School of Medicine, Gifu University
  • YOKOYAMA Ryujiro
    Radiology Services, Gifu Univ. School of Medicine and University Hospital
  • KANEMATSU Masayuki
    Radiology Services, Gifu Univ. School of Medicine and University Hospital Department of Radiology, Gifu Univ. School of Medicine and University Hospital
  • HOSHI Hiroaki
    Department of Radiology, Division of Tumor Control, Graduate School of Medicine, Gifu University

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Other Title
  • 体幹部X線CT画像における脊柱の正中矢状面を利用した椎体の骨密度と彎曲角度の自動計測法

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Abstract

The number of patients with osteoporosis is increasing every year in Japan. The bone-mineral-density (BMD) and spinal curvature are two important factors related to the fractures and osteoporosis. Recently, multi-detector-row CT images are widely used in clinical medicine and may have the potential for osteoporosis diagnosis. The development of a computer-aided diagnosis (CAD) system that can support the osteoporosis diagnosis is now required. This study proposes a method that can measure the distributions of BMD in each of vertebral trabecular bones and angles of spinal curvatures automatically on torso CT images. This method extracts the regions of the vertebral bones firstly and then generates a sagittal plane of the human spine. Finally, 4 corner points of each vertebral bone region are identified and used for measuring the BMD distributions and spinal curvatures. This method was applied to 20 CT cases and the results were compared with the gold standard that were generated by a medical expert. The errors of the average value of BMD have the mean value of 6.93 mg/cm3 (std.dev.: 6.82) . The angles have the mean value of 4.62 degrees (std. dev.: 3.23) in thoracic region and 4.40 degrees (std. dev.: 5.08) in abdomen. These results showed a good performance of our purposed method and possibility for supporting the CAD of osteoporosis diagnosis.

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