工業化学物質による染色体の変化

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タイトル別名
  • CHROMOSOME CHANGES INDUCED BY INDUSTRIAL CHEMICALS
  • コウギョウ カガク ブッシツ ニヨル センショクタイ ノ ヘンカ

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抄録

Radiation-induced chromosome damage has been widely recognized and intensively studied. Recently, attention is placed on chromosome changes induced by various industrial chemicals. In case of occupational exposure to ionizing radiation, chromosome breaks are characterized as one of the most sensitive biological effcts. Chromosome breaks among industrial workers who dealt with benzene, vinyl chloride monomer or styrene have also been reported. Moreover, relationship between chromosome changes and exposure to environmental lead, cadmium and mercury compounds have been studied. Ionizing radiation, benzene and vinyl chloride monomer are known also as industrial carcinogens and attention is now placed on carcinogenicity of clastogens or chromosome breaking agents. In the present paper, our studies on in vitro chromosome breakage induced by benzene and its metabolites as well as cadmium, lead, and chromium compounds are reviewed. Also, inhibition of repair of radiation-induced chromosome breaks by clastogens is reported. Significance of cytogenetic studies in industrial medicine is also discussed.

収録刊行物

  • 産業医学

    産業医学 21 (1), 3-10, 1979

    社団法人 日本産業衛生学会

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