トリフェニルすずの好中球機能　　とくにスーパーオキサイド（Ｏ・２｀－´）生成および脱か粒に及ぼす影響

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タイトル別名
  • EFFECT OF TRIPHENYLTIN CHLORIDE ON SUPEROXIDE (O<sub>2</sub>) PRODUCTION IN HUMAN NEUTROPHILS
  • トリフェニル スズ ノ コウチュウキュウ キノウ トクニ スーパーオキサイド

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抄録

Brief treatment (3 min at 37°C) of human neutrophils with triphenyltin chloride (TPTCl) resulted in a dose-dependent inhibition of superoxide (O2) production stimulated by concanavalin A+cytochalasin D. It was considered from the following findings that the inhibition may be caused by some functional disorders of neutrophils: 1) _O2 generated by xanthine oxidase-acetaldehyde system was not inhibited by TPTCl. 2) There was no change in cell viability after treatment with TPTCl. When the other phenyltin compounds were examined, the relative potencies of inhibitory effect were shown to be in the order of TPTCl>diphenyltin dichloride>phenyltin trichloride>tetraphenyltin on a molar basis. Lysosomal enzyme release caused by neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine (FMLP) was also inhibited by TPTCl. These results suggest that TPTCl inhibits the common pathway (s) of the two stimulus responses.

収録刊行物

  • 産業医学

    産業医学 26 (2), 165-169, 1984

    社団法人 日本産業衛生学会

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