Method for simultaneous determination of six metabolites of toluene, xylene and ethylbenzene, and its application to exposure monitoring of workers in a printing factory with gravure machines.

DOI Web Site Web Site PubMed 3 Citations
  • SAKAI Tadashi
    Center of Occupational Medicine, Tokyo Labor Accident Hospital
  • TAKEUCHI Yukiko
    Center of Occupational Medicine, Tokyo Labor Accident Hospital
  • IKEYA Yumiko
    Center of Occupational Medicine, Tokyo Labor Accident Hospital
  • ARAKI Takaharu
    Center of Occupational Medicine, Tokyo Labor Accident Hospital
  • USHIO Koichi
    Center of Occupational Medicine, Tokyo Labor Accident Hospital

Bibliographic Information

Other Title
  • トルエン，キシレン，エチルベンゼンの尿中代謝物６種の同時測定法とグラビア印刷作業者での生物学的モニタリング
  • トルエン キシレン エチルベンゼン ノ ニョウチュウ タイシャブツ 6シュ ノ

Search this article

Description

For the biological monitoring of exposure to solvent composed of toluene, xylene, and ethylbenzene used in a printing factory with gravure machines, we developed a HPLC method for the simultaneous determination of urinary metabolites of this solvent, i.e. hippuric acid, o-, m-, and p- methylhippuric acid, mandelic acid and phenylglyoxylic acid. Except for phenylglyoxylic acid, urinary concentrations of the metabolites determined by the present method correlated well with the air concentrations of the respective solvent components. Hence the present method is useful in monitoring solvent exposure. In 91 workers of the printing factory and 53 control subjects, we also determined the concentrations of some phenolic metabolites and confirmed that o-cresol is a useful indicator for monitoring toluene exposure.

Journal

  • Sangyo Igaku

    Sangyo Igaku 31 (1), 9-16, 1989

    Japan Society for Occupational Health

Citations (3)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top