Pharmacokinetic studies of terguride (2): Absorption and excretion in rabbits.

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  • Ｔｅｒｇｕｒｉｄｅの体内動態（第２報）：ウサギにおける吸収および排せつ

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The absorption and excretion of terguride in rabbits were studied.<BR> 1. After oral administration of 14C-terguride (1 mg/kg) to female rabbits, the radioactivity in plasma reached the maximum (Cmax) at 1hr and disap peared with a half-life of 1.9hr. Concentration of terguride in plasma reached Cmax at 0.25 ?? 1 hr and disappeared with a half-life of 1.2hr. Similar plasma kinetics was observed in male rabbits. Urinary and fecal excretion within 7days after oral dosing was 41 and 53%, respectively.<BR> 2. The bioavailability of terguride after oral administration was about 39%<BR> 3. Food intake before oral administration of unlabelled terguride (0.2mg/animal) decreased (about 30%) the Cmax, whereas the increase was induced by neutralization of stomach pH, however, no effect of their treatment on Tmax and availability was found.

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